Where is histamine stored

We propose that the storage of histamine in vertebrate mast cells and its use as an inflammatory messenger was established in primitive reptiles Lepidosauria approximately million years ago.

This same feature seems to have developed independently in Perciform fish much more recently in the Lower Eocene, between 55 and 45 million years ago, a short period during which the great majority of Percomorph families appeared. Abstract Mast cells are important as initiators and effectors of innate immunity and regulate the adaptive immune responses. Publication types Research Support, Non-U. Substances Serotonin Histamine. These are found in abundance around areas particularly prone to injury, such as blood vessels and extremities.

Histamine is also stored in a special type of white blood cell found in the blood stream called basophils. Histamine from these sources is used mainly as part of your body's immune system, where the histamine release is stimulated by Immunoglobulin E, a type of mammalian antibody.

The antibody is triggered by a number of causes, usually an invading bacterium or virus, but it could also be a pollen cell or an allergic reaction to something the body has come into contact with. In any case, whatever triggers the release of the antibody results in the stored histamine being released into the body.